Two goals from Ronaldo, the first after only two minutes, and one for Higuaín saw Real Madrid win 0-3 at Athletic Bilbao. Ronaldo now has fifty for the season so far.
An under-strength Barcelona still managed to ease past struggling Zaragoza, with Cristian Tello grabbing two goals after Thiago had given the Catalans the lead after twenty minutes of play.
Agirretxe scored twice within the first fifteen minutes to give fourth placed Real Sociedad victory at Rayo Vallecano.
Two goals from Falcao and one apiece for Diego Costa, Raul Garcia and Filipe Luis were more than enough to see Atlético Madrid cruise past Granada, 0-5 the scoreline in that match.