A round of midweek matches in La Liga and Málaga moved up the table after a 2-0 win over Almeria, Tissone and Portillo the scorers.
Barcelona and Atlético Madrid both equalled their best starts to a season, six wins out of six.
Barcelona were 4-1 winners against Real Sociedad, Neymar grabbing his first goal for the club. Messi, Busquets and Bartra added three more and de la Bella replied for Real.
Atlético beat Osasuna 2-1, Diego Costa grabbing a pair for the home side and Oriol Riera pulling one back for the visitors, all the goals coming in the first half.
An injury time goal from Jonas saw Valencia scrape a win over Granada and two goals from Ronaldo helped Real Madrid overcome Elche 1-2, Boakye replying for the home side. Eight yellow cards in this match.
Sevilla got their first win of the season, 4-1 against Rayo Vallecano. Rakitic and Bacca both bagged a brace with Adrián González on the scoresheet for Rayo.