Not to be outdone, Lionel Messi also bagged a hat-trick as Barcelona eased past city rivals Espanyol 5-1 on Sunday, Pique and Pedro scoring one each and Garcia de la Fuente grabbing a goal for the visitors.
David Moyes suffered his first defeat as his Real Sociedad team were hammered 4-0 by Villarreal, Soriano Llido, Cheryshev and Bardonado with two being responsible for the damage.
An early goal from Bacca was enough to see Sevilla safely past Rayo Vallecano and they remain in fourth place.
Two late goals, Negredo in the 83rd minute and the appropriately named Success in the 89th minute saw Granada and Valencia play out a 1-1 draw.